ParkinsonCanadaV1, Main, Exploration, bibRecord, 000729

Familial aggregation of Parkinson's disease in the Faroe Islands.

Identifieur interne : 000729 ( Main/Exploration ); précédent : 000728; suivant : 000730

Familial aggregation of Parkinson's disease in the Faroe Islands.

Auteurs : Maria Skaalum Petersen ; Sara Bech ; Ekaterina Nosova ; Jan Aasly ; Matthew J. Farrer

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:25600277

Descripteurs français

Wicri :
- geographic : Danemark.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Cohort Studies, Denmark (epidemiology), Family Health, Female, Genetic Testing, Humans, Male, Middle Aged, Parkinson Disease (epidemiology), Parkinson Disease (genetics), Residence Characteristics, Risk Factors.
MESH :
- geographic , epidemiology : Denmark.
- epidemiology : Parkinson Disease.
- genetics : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Cohort Studies, Family Health, Female, Genetic Testing, Humans, Male, Middle Aged, Residence Characteristics, Risk Factors.

Abstract

The Faroe Islands are a geographic population isolated in the North Atlantic with a high prevalence of Parkinson's disease (PD). Although environmental risk factors are well described, the familial aggregation of PD on the Islands has yet to be explored. Complete ascertainment of all patients with PD was performed, including 217 cases and 251 control subjects. All patients were neurologically assessed and diagnosed using UK Brain Bank criteria and Hohn and Yahr staging. Comprehensive genealogical and detailed cartographic analyses were performed. Relative risk and risk ratios were calculated with respect to the general population. Patients with PD in the Faroes have a higher age at symptom onset and diagnosis than for neighboring countries. Clinically, patients are similar; however, they are more likely to have affected relatives than randomly selected control subjects, matched by sex and age. Disease is most prevalent within two geographic regions. Overall, the relative risk for PD was 2.3 (95% confidence interval [CI], 1.2-4.3; P = 0.008) for siblings and 1.4 (95% CI, 1.01-1.99, P = 0.04) for first cousins. The etiology and excess prevalence of PD on the Faroes is complicated. Regional and familial clustering, and subsequent segregation analysis, suggests the disease best fits a genetic etiology with limited support for an environmental contribution. Pedigree-based analysis of PD on the Faroe Islands which has few founders and a relatively homogeneous background may elaborate on these possibilities and their joint contribution.

DOI: 10.1002/mds.26132
PubMed: 25600277

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">The Faroe Islands are a geographic population isolated in the North Atlantic with a high prevalence of Parkinson's disease (PD). Although environmental risk factors are well described, the familial aggregation of PD on the Islands has yet to be explored. Complete ascertainment of all patients with PD was performed, including 217 cases and 251 control subjects. All patients were neurologically assessed and diagnosed using UK Brain Bank criteria and Hohn and Yahr staging. Comprehensive genealogical and detailed cartographic analyses were performed. Relative risk and risk ratios were calculated with respect to the general population. Patients with PD in the Faroes have a higher age at symptom onset and diagnosis than for neighboring countries. Clinically, patients are similar; however, they are more likely to have affected relatives than randomly selected control subjects, matched by sex and age. Disease is most prevalent within two geographic regions. Overall, the relative risk for PD was 2.3 (95% confidence interval [CI], 1.2-4.3; P = 0.008) for siblings and 1.4 (95% CI, 1.01-1.99, P = 0.04) for first cousins. The etiology and excess prevalence of PD on the Faroes is complicated. Regional and familial clustering, and subsequent segregation analysis, suggests the disease best fits a genetic etiology with limited support for an environmental contribution. Pedigree-based analysis of PD on the Faroe Islands which has few founders and a relatively homogeneous background may elaborate on these possibilities and their joint contribution.</div>
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<name sortKey="Petersen, Maria Skaalum" sort="Petersen, Maria Skaalum" uniqKey="Petersen M" first="Maria Skaalum" last="Petersen">Maria Skaalum Petersen</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

Familial aggregation of Parkinson's disease in the Faroe Islands.

Familial aggregation of Parkinson's disease in the Faroe Islands.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.